Dissolution of gall stones with an ursodeoxycholic acid menthol preparation: a controlled prospective double blind trial.

Abstract

In a controlled prospective double blind trial patients with cholesterol gall bladder stones are treated with ursodeoxy-cholic acid (group A: UDCA 11.1 mg/kg per day; n = 16) and Ursomenth respectively (group B: a mixture of UDCA/menthol: 4.75 mg/kg per day each; n = 17). With same stone number and size (10-12 mm) there is a complete dissolution rate in group A of 38%, and of 53% in group B within 15-16.9 months. The response rate (complete + partial dissolution) amounted to 75% and 76% respectively. In group A there is one case of stone calcification, in group B none. Both preparations are free of unwanted effects. This suggests that the cyclic monoterpene menthol enhances the effect of UDCA and is of comparable effect to a mixture of six different terpenes used in former times.

• Authors: M Leuschner, U Leuschner, D Lazarovici, W Kurtz, A Hellstern
• Journal: Gut (Gut) Vol. 29 Issue 4 Pg. 428-32 (Apr 1988) ISSN: 0017-5749 [Print] England
• PMID: 3286383 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Deoxycholic Acid
• Ursometh
• Menthol
• Ursodeoxycholic Acid

Topics

• Adult
• Aged
• Cholelithiasis (pathology, therapy)
• Clinical Trials as Topic
• Deoxycholic Acid (analogs & derivatives)
• Double-Blind Method
• Drug Combinations (therapeutic use)
• Female
• Humans
• Male
• Menthol (therapeutic use)
• Middle Aged
• Prospective Studies
• Ursodeoxycholic Acid (therapeutic use)