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Subacute acetaminophen overdose after incremental dosing.

Abstract
A case of acetaminophen poisoning following the ingestion of 26 g of acetaminophen by incremental dosing over a 25-h period is reported. At presentation, seven h after the last ingestion, the patient experienced hematemesis, the acetaminophen level was 150 micrograms/mL, and the SGOT was normal. The patient recovered uneventfully following N-acetylcysteine therapy. A review of the pharmacology and toxicity of acetaminophen is discussed. The case illustrates the problems of judging hepatotoxic potential in a multiple-dose acetaminophen ingestion and describes the successful use of N-acetylcysteine in a patient with a "subacute" acetaminophen overdose.
AuthorsR D Mathis, J S Walker, D W Kuhns
JournalThe Journal of emergency medicine (J Emerg Med) 1988 Jan-Feb Vol. 6 Issue 1 Pg. 37-40 ISSN: 0736-4679 [Print] United States
PMID3283215 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Acetaminophen
  • Acetylcysteine
Topics
  • Acetaminophen (administration & dosage, blood, poisoning)
  • Acetylcysteine (therapeutic use)
  • Adolescent
  • Emergencies
  • Humans
  • Male
  • Time Factors

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