HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clomipramine treatment of agoraphobic women. An eight-week controlled trial.

Abstract
The efficacy of clomipramine hydrochloride in the treatment of agoraphobia was investigated in an eight-week placebo-controlled double-blind study. One hundred eight women diagnosed as agoraphobic by DSM-III guidelines were randomly assigned to the clomipramine or placebo group; 70 women (mean age, 36.6 years) completed the eight-week trial. The study medication was prescribed on the basis of weekly increments to a maximum of 300 mg/d, with a mean dosage at week 8 in the clomipramine hydrochloride group of 82.8 mg/d. Assessments performed prior to the trial and at the four- and eight-week points included the completion of standardized questionnaires and daily diaries, as well as the administration of a Behavioral Approach Test. Clomipramine was significantly superior to the placebo on several indexes of phobic symptoms and on measures of depression and dysphoria. Results are discussed in terms of the hypothesized action of clomipramine and the pattern of significant findings.
AuthorsD G Johnston, I E Troyer, S F Whitsett
JournalArchives of general psychiatry (Arch Gen Psychiatry) Vol. 45 Issue 5 Pg. 453-9 (May 1988) ISSN: 0003-990X [Print] United States
PMID3282481 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Placebos
  • Clomipramine
Topics
  • Adult
  • Agoraphobia (drug therapy, psychology, therapy)
  • Clinical Trials as Topic
  • Clomipramine (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Medical Records
  • Phobic Disorders (drug therapy)
  • Placebos
  • Psychiatric Status Rating Scales

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: