HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Detection of circulating antibodies to purified keratinolytic proteinase in sera from guinea pigs infected with Microsporum canis by enzyme-linked immunosorbent assay.

Abstract
A keratinolytic proteinase (KPase) which is regarded as an important factor in the pathogenesis of dermatophytosis was isolated and purified from Microsporum (M.) canis culture filtrates. Enzyme-linked immunosorbent assay (ELISA) was used to determine the occurrence of circulating antibodies to this enzyme in sera samples from guinea pigs with superficial fungal infections caused by M. canis. Of sera samples from guinea pigs infected with M. canis, 75% were reactive within 10 weeks, however, those ELISA values were relatively low compared with those from guinea pigs immunized with KPase. The presence of circulating antibodies was first detected 2 weeks post inoculation with M. canis, corresponding to the period when the lesions were most severe. The titers of the ELISA antibodies reached a peak at 4 weeks; at that time the lesions had disappeared completely.
AuthorsK H Lee, J B Lee, M G Lee, D H Song
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 280 Issue 1 Pg. 45-9 ( 1988) ISSN: 0340-3696 [Print] Germany
PMID3281601 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Fungal
  • Peptide Hydrolases
  • keratinase
Topics
  • Animals
  • Antibodies, Fungal (analysis, biosynthesis)
  • Dermatomycoses (immunology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Guinea Pigs
  • Male
  • Microsporum (enzymology, immunology)
  • Peptide Hydrolases (immunology)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: