Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to compare the cost-effectiveness of edoxaban with LMWH (Model 1) and warfarin (Model 2) to support clinicians and hospitals when choosing an anticoagulant to manage CAT. MATERIALS AND METHODS: Cost-effectiveness analyses were performed using Markov state-transition models over a timeframe of 5 years, in a hypothetical, 64 years-old patients cancer population with an index VTE event. Transition probabilities, costs, quality-adjusted life years (QALYs) and risk reductions were either derived from the literature, estimated or calculated. A willingness-to-pay limit of 3 Gross Domestic Product ( GDP) per head was used. Deterministic and probabilistic sensitivity analyses were performed for robustness. The main outcome of this study was the incremental cost-effectiveness ratio (ICER), expressed as cost per QALY gained. RESULTS: Model 1 base case analysis demonstrated dominance of edoxaban compared to LMWH, with an ICER of $5204.46, representing cost saved per QALY lost. In Model 2, edoxaban was associated with a $736.90 cost increase vs. warfarin, with an ICER of $2541.03. Sensitivity analyses confirmed base-case results. CONCLUSION:
Edoxaban represents a cost-saving alternative to LMWH for the management of CAT and is cost-effective vs. warfarin.
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Authors | Danilo G Lopes, Arturo Tamayo, Bernhard Schipp, Timo Siepmann |
Journal | Thrombosis research
(Thromb Res)
Vol. 196
Pg. 4-10
(12 2020)
ISSN: 1879-2472 [Electronic] United States |
PMID | 32810773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anticoagulants
- Heparin, Low-Molecular-Weight
- Pyridines
- Thiazoles
- Warfarin
- edoxaban
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Topics |
- Anticoagulants
(therapeutic use)
- Brazil
- Cost-Benefit Analysis
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Humans
- Neoplasms
(complications, drug therapy)
- Pyridines
- Quality-Adjusted Life Years
- Thiazoles
- Thrombosis
- Warfarin
(therapeutic use)
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