Objective: To investigate the clinical and diagnostic value of liver stiffness measurement (LSM) for the evaluation and comparison of
aspartate aminotransferas/platelet ratio index (APRI),
fibrosis 4 indexes (FIB-4) and
NAFLD fibrosis score (NFS) with
liver fibrosis staging in relation to
nonalcoholic fatty liver disease (
NAFLD). Methods: 103 cases with
NAFLD who met the inclusion criteria confirmed by liver biopsy were selected for retrospective analysis. The results of serological tests and LSM were recorded. The APRI, FIB-4 and NFS were calculated. The accuracy and applicability of four
liver fibrosis models in the diagnosis of
liver fibrosis in
NAFLD patients were compared with the receiver operating characteristic curve (ROC), and the diagnostic cut-off value of LSM was established. Results: Varying degrees of LSM, APRI, FIB-4 and NFS had shown positive correlations with the increasing degree of
liver fibrosis. Among them, LSM was positively correlated with the degree of
liver fibrosis, and the correlation coefficient was r = 0.727, P < 0.0001. Consistent with this, the area under the receiver operating characteristic curve, sensitivity, and specificity of LSM diagnosis of
liver fibrosis in different stages was significantly higher than APRI, FIB-4 and NFS. Area under receiver operating characteristic curve of LSM was 0.862 and 0.928 for significant
liver fibrosis (f ≥ 2), and advanced
liver fibrosis (f ≥ 3). Conclusion: LSM has a good diagnostic exclusion value for
NAFLD-induced
fibrosis, and its sensitivity and specificity are better than APRI, FIB-4 and NFS.