Abstract |
Ischemia may increase synaptic concentrations of glutamate, which may cause neuronal damage. Drugs that antagonize glutamate's effects may reduce this type of damage. MK-801, an N-methyl-D-aspartate receptor antagonist that readily enters the central nervous system, was evaluated in two focal central nervous system ischemia models: a multiple cerebral embolic model and a rabbit spinal cord ischemia model. When animals were treated five minutes after the onset of injury, MK-801 was effective in reducing ischemic damage in both models. In the multiple cerebral embolic model, the average dose of microspheres trapped in the brain increased from 344.8 +/- 51.4 micrograms (n = 29) in controls to 534 +/- 41.4 micrograms (n = 17) in the MK-801-treated group. Similarly, in the rabbit spinal cord ischemia model, the average ischemia duration increased from 28.9 +/- 1.7 minutes (n = 52) in controls to 50.6 +/- 3.9 minutes (n = 12) in the MK-801-treated group. These results suggest that this glutamate antagonist should be useful for the treatment of stroke.
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Authors | A Kochhar, J A Zivin, P D Lyden, V Mazzarella |
Journal | Archives of neurology
(Arch Neurol)
Vol. 45
Issue 2
Pg. 148-53
(Feb 1988)
ISSN: 0003-9942 [Print] United States |
PMID | 3277597
(Publication Type: Journal Article)
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Chemical References |
- Dibenzocycloheptenes
- Excitatory Amino Acid Antagonists
- Dizocilpine Maleate
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Dibenzocycloheptenes
(therapeutic use)
- Disease Models, Animal
- Dizocilpine Maleate
- Excitatory Amino Acid Antagonists
- Intracranial Embolism and Thrombosis
(drug therapy, physiopathology)
- Ischemia
(drug therapy, physiopathology)
- Ischemic Attack, Transient
(drug therapy, physiopathology)
- Male
- Rabbits
- Spinal Cord
(blood supply)
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