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Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide.

AuthorsOnima Chowdhury, Jennifer O'Sullivan, Nikolaos Barkas, Guanlin Wang, Gemma Buck, Angela Hamblin, Ayalew Tefferi, Haifa K Al-Ali, Giovanni Barosi, Timothy Devos, Heinz Gisslinger, Qian Jiang, Jean-Jacques Kiladjian, Ruben Mesa, Francesco Passamonti, Vincent Ribrag, Gary Schiller, Alessandro M Vannucchi, Daobin Zhou, Mary Frances McMullin, Jianhua Zhong, Robert Peter Gale, Adam J Mead, RESUME trialists
JournalLeukemia (Leukemia) Vol. 35 Issue 4 Pg. 1197-1202 (04 2021) ISSN: 1476-5551 [Electronic] England
PMID32770086 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Thalidomide
  • pomalidomide
Topics
  • Disease Management
  • Disease Susceptibility
  • Erythrocyte Transfusion (adverse effects, methods)
  • Humans
  • Mutation
  • Myeloproliferative Disorders (complications, genetics)
  • Primary Myelofibrosis (diagnosis, etiology, therapy)
  • Spliceosomes (genetics)
  • Thalidomide (analogs & derivatives, therapeutic use)
  • Treatment Outcome

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