Serum interleukin-2 receptor in systemic lupus erythematosus and rheumatoid arthritis.

• Abstract: Interleukin-2 receptor (IL-2R) is expressed on activated lymphocyte after stimulation with antigen or interleukin-2 (IL-2), meanwhile soluble form of the receptor is released. Using enzyme-linked immunosorbent assay, serum IL-2R levels were determined in 34 healthy controls, 61 patients with systemic lupus erythematosus (SLE) and 32 patients with rheumatoid arthritis (RA), yielding mean +/- SD values of 355 +/- 89, 807 +/- 453 and 567 +/- 210 U/ml respectively. In both SLE and RA patients, the active disease group had more markedly elevated serum IL-2R levels compared with those of the inactive group. In patients with SLE, elevated serum IL-2R is associated with lymphopenia, renal disorders, decreased C3 level and increased anti-DNA, thus make it a good parameter to monitor disease activity in SLE.
• Authors: G L Lee, M Y Chen, C Y Chuang, C Y Chen (Affiliation: Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, ROC.)
• Journal: Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology (Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi) Vol. 21 Issue 1 Pg. 16-22 (Feb 1988) ISSN: 0253-2662 [Print] TAIWAN
• PMID: 3264781 (Publication Type: Journal Article)

Chemical References

• Receptors, Interleukin-2

Topics

• Adolescent
• Adult
• Arthritis, Rheumatoid (immunology)
• Female
• Humans
• Lupus Erythematosus, Systemic (immunology)
• Male
• Middle Aged
• Receptors, Interleukin-2 (analysis)