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Recombinant human interleukin 1 alpha enhances anti-Listeria resistance in both genetically resistant and susceptible strains of mice.

Abstract
In this study we show that recombinant human IL-1 alpha (rhIL-1 alpha) protects both genetically resistant and susceptible strains of mice against Listeria monocytogenes infection. Similar levels of protection were observed in all strains tested. These data suggest that innate susceptibility to an infectious agent may not abrogate the ability of rhIL-1 alpha to enhance antibacterial resistance.
AuthorsR S Kurtz, J T Roll, C J Czuprynski
JournalImmunology letters (Immunol Lett) Vol. 18 Issue 4 Pg. 289-92 (Aug 1988) ISSN: 0165-2478 [Print] Netherlands
PMID3263318 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Interleukin-1
Topics
  • Animals
  • Interleukin-1 (pharmacology)
  • Listeriosis (genetics, immunology, prevention & control)
  • Mice
  • Mice, Inbred Strains
  • Species Specificity

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