Disease activity in systemic lupus erythematosus related to a range of antibodies binding DNA and synthetic polynucleotides.

Abstract

Antibodies to dDNA, nDNA, Z-DNA, poly(dT), poly(I), poly(dG.dC), poly(dA.dT), and total IgG and IgM were measured in five serial bleeds from 39 patients with systemic lupus erythematosus (SLE). The main findings were that those patients with renal disease form a distinct subset whose antibody levels correlate well with disease activity; anti-poly(dT) antibodies showed the best overall correlation with disease activity; and discriminant functional analysis demonstrated a major improvement in correlation of disease activity with combinations of antibodies to dDNA/nDNA/Z-DNA/poly(dT) (generally 50% or more were correctly classified) than with dDNA or nDNA alone (generally less than 25% correct). Serum IgG (but not IgM) correlated significantly (p less than 0.01) with six antibodies, suggesting that polyclonal activation plays a part in the development of these antibodies, though antibody cross reactivity is not excluded.

• Authors: D A Isenberg, C Dudeney, W Williams, A Todd-Pokropek, B D Stollar
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 47 Issue 9 Pg. 717-24 (Sep 1988) ISSN: 0003-4967 [Print] England
• PMID: 3263086 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Antibodies, Antinuclear
• Immunoglobulin G
• Immunoglobulin M
• Polynucleotides
• DNA

Topics

• Antibodies (immunology)
• Antibodies, Antinuclear (immunology)
• DNA (immunology)
• Humans
• Immunoglobulin G (analysis)
• Immunoglobulin M (analysis)
• Lupus Erythematosus, Systemic (immunology)
• Lupus Nephritis (immunology)
• Polynucleotides (immunology)