Abstract | BACKGROUND:
Concurrent chemoradiotherapy (CCRT) is expected to improve local and systemic disease control and has been established as a standard therapy for several types of solid tumors. Considering the benefits of frontline radiation and pegaspargase in localized extranodal natural killer (NK)/ T-cell lymphoma, nasal type (ENKTL), we conducted a phase II study on pegaspargase-based CCRT to explore an effective treatment. MATERIALS AND METHODS: In this study, 30 patients with newly diagnosed nasal ENKTL in stages IE to IIE received CCRT (radiation 50 Gy and two cycles of pegaspargase 2,500 unit/m2 every 3 weeks). Four courses of pegaspargase were performed after CCRT. RESULTS: The patients completed CCRT and four cycles of pegaspargase. The complete remission (CR) rate was 90%, with a 95% confidential interval (CI) of 73.5%-97.9% after CCRT. The CR rate was 100% (95% CI, 88.4%-100%) at the end of the treatment. The 2-year overall survival and progression-free survival rates were 90.9% (95% CI, 78.4%-100%) and 92.8% (95% CI, 83.2%-100%), respectively. The major adverse events were in grades 1-2. CONCLUSION: Preliminary data indicate that pegaspargase combined with concurrent radiotherapy for newly diagnosed patients with nasal ENKTL was efficacious and well tolerated. Registered at www.chictr.org. CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR-OIC-15007662. IMPLICATIONS FOR PRACTICE:
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Authors | Hua Wang, Liang Wang, Chun Li, Zhijun Wuxiao, Guanjun Chen, Wei Luo, Yue Lu |
Journal | The oncologist
(Oncologist)
Vol. 25
Issue 11
Pg. e1725-e1731
(11 2020)
ISSN: 1549-490X [Electronic] England |
PMID | 32627928
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Copyright | © 2020 The Authors. The Oncologist published by Wiley Periodicals LLC on behalf of AlphaMed Press. |
Chemical References |
- Polyethylene Glycols
- pegaspargase
- Asparaginase
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Asparaginase
(therapeutic use)
- Chemoradiotherapy
- Female
- Humans
- Killer Cells, Natural
(pathology)
- Lymphoma, Extranodal NK-T-Cell
(drug therapy, radiotherapy)
- Male
- Middle Aged
- Neoplasm Staging
- Polyethylene Glycols
(therapeutic use)
- Retrospective Studies
- Treatment Outcome
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