In order to improve the anticancer therapeutic efficacy and postoperative recovery efficacy, the novel anticancer therapeutic system should have the ability to promote angiogenesis after anticancer
therapy besides the excellent anticancer therapeutic efficacy. We present herein a magnetic targeting multifunctional anticancer therapeutic system based on
cobalt nanowires (CoNWs) for anticancer
therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target
therapy. Besides, drug loading/release characterization reveals that the CoNWs interact with
doxorubicin (DOX) by electrostatic interaction, and accordingly form a composite which can release DOX with temperature increase under near-infrared light (NIR) treatment. And anticancer test reveals that the nanowires loaded with the DOX (CoNWs-DOX) can produce an effective chemo-photothermal synergistic
therapeutic effect against murine
breast cancer cell lines (4T1) and human
osteosarcoma cell lines (MG63) under NIR treatment. Furthermore, angiogenesis assessment reveals that the released
cobalt ion from the nanowires can significantly enhance the angiogenesis efficacy after
cancer treatment. These results suggest that the constructed anticancer therapeutic system provides a promising multifunctional platform for
cancer treatment and postoperative recovery.