[Influence of enzyme inducers and inhibitors of the metabolism of xenobiotics and of the coenzyme forms of vitamins B1 and B2 on the anti-inflammatory effect of voltaren].

Abstract

In experiments on 245 male rats there was studied the influence of an inductor of xenobiotic metabolism enzymes, phenobarbital, an inhibitor of microsomal monooxygenases, cobalt chloride, and also coenzyme forms of vitamins B1 and B2, thiamine diphosphate and flavin mononucleotide on the anti-inflammatory effect of voltaren evaluated according to inhibition of an increase of the limb edema, a decrease of pain sensitivity, the blood level of fucose and the liver level of malondialdehyde in rats with adjuvant arthritis. Phenobarbital weakens the anti-inflammatory action of voltaren but at the same time cobalt chloride and thiamine diphosphate potentiate the therapeutic effect of voltaren. Flavin mononucleotide fails to modify the effect of voltaren but decreases however its toxicity.

• Authors: N A Stanislavchuk, A A Pentiuk, G Z Lychik, A P Lychko, N B Lutsiuk
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Mar-Apr Vol. 51 Issue 2 Pg. 69-71 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie induktorov i ingibitorov fermentov metabolizma ksenobiotikov, kofermentnykh form vitaminov B1 i B2 na protivovospalitel'nyĭ éffekt vol'tarena.
• PMID: 3259936 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acetanilides
• Aniline Compounds
• Anti-Inflammatory Agents, Non-Steroidal
• Diclofenac
• Cobalt
• Flavin Mononucleotide
• cobaltous chloride
• Thiamine Pyrophosphate
• aniline
• Phenobarbital

Topics

• Acetanilides (metabolism)
• Aniline Compounds (metabolism)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use, toxicity)
• Arthritis, Experimental (drug therapy, metabolism)
• Cobalt (pharmacology)
• Diclofenac (therapeutic use, toxicity)
• Drug Evaluation, Preclinical
• Drug Interactions
• Edema (chemically induced, drug therapy, metabolism)
• Flavin Mononucleotide (pharmacology)
• Male
• Phenobarbital (pharmacology)
• Rats
• Rats, Inbred Strains
• Thiamine Pyrophosphate (pharmacology)