[Mechanism of the anti-inflammatory and analgesic effects of benzofurocaine and voltaren].

Abstract

Non-narcotic analgesics benzofurocaine and voltaren (10% of LD50) were shown to exert the protective effect on rats in castor oil-induced diarrhea, to decrease in mice the degree of pain reaction under the influence of acetylcholine, acetic acid and thermic stimulation.

• Authors: G I Stepaniuk
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Mar-Apr Vol. 51 Issue 2 Pg. 66-8 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K mekhanizmu protivovospalitel'nogo i boleutoliaiushchego éffektov benzofurokaina i vol'tarena.
• PMID: 3259935 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anesthetics, Local
• Anti-Inflammatory Agents, Non-Steroidal
• Benzofurans
• Kinins
• Prostaglandin Antagonists
• Diclofenac
• Castor Oil
• benzofurocaine

Topics

• Anesthetics, Local (therapeutic use)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Benzofurans
• Castor Oil
• Diarrhea (chemically induced, drug therapy)
• Diclofenac (therapeutic use)
• Drug Evaluation, Preclinical
• Kinins (antagonists & inhibitors)
• Male
• Mice
• Pain (physiopathology)
• Prostaglandin Antagonists (therapeutic use)
• Rats
• Sensory Thresholds (drug effects)
• Spasm (drug therapy, etiology)