[Synovial level of interleukin 1 and C3a in chronic polyarthritis, psoriatic arthritis and activated arthritis].

Abstract

Concentrations of interleukin-1 (IL-1), C3a des Arg and immune complexes (IC) were investigated in knee effusions of patients with rheumatoid arthritis (RA; n = 36), psoriatic arthritis (Ps.A., n = 19) and osteoarthritis (n = 7). Maximal concentrations of IC and C3a des Arg were found in RA patients, high IL-1-activities could be demonstrated in patients with Ps.A. and seropositive RA. We found significant correlations between IL-1 and C3a des Arg, IL-1 and IC and C3a des Arg, and IC in Ps.A. patients, but not in RA or osteoarthritis patients. The role of IL-1 in the chronic inflammatory response and joint destruction in inflammatory joint diseases is discussed.

• Authors: E Hermann, P Vogt, W Hagmann, A Dunky, W Müller
• Journal: Zeitschrift fur Rheumatologie (Z Rheumatol) 1988 Jan-Feb Vol. 47 Issue 1 Pg. 20-5 ISSN: 0340-1855 [Print] Germany
• Vernacular Title: Synoviaspiegel von Interleukin-1 und C3a bei chronischer Polyarthritis, Psoriasisarthritis und aktivierter Arthrose.
• PMID: 3259355 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigen-Antibody Complex
• Complement C1
• Complement C3
• Interleukin-1
• complement C3a, des-Arg-(77)-
• Complement C1q
• Complement C3a
• Complement Activating Enzymes

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigen-Antibody Complex (metabolism)
• Arthritis (immunology)
• Arthritis, Rheumatoid (immunology)
• Complement Activating Enzymes (metabolism)
• Complement C1 (metabolism)
• Complement C1q
• Complement C3 (analogs & derivatives, metabolism)
• Complement C3a
• Female
• Humans
• Interleukin-1 (metabolism)
• Male
• Middle Aged
• Osteoarthritis (immunology)
• Psoriasis (immunology)
• Synovial Fluid (immunology)