Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients.

Abstract

In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.

• Authors: Ming Tong, Yu Jiang, Da Xia, Ying Xiong, Qing Zheng, Fang Chen, Lianhong Zou, Wen Xiao, Yimin Zhu
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 222 Issue 6 Pg. 894-898 (08 17 2020) ISSN: 1537-6613 [Electronic] United States
• PMID: 32582936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Cell Adhesion Molecules
• Chemokine CX3CL1
• Vascular Cell Adhesion Molecule-1
• Intercellular Adhesion Molecule-1
• AOC3 protein, human
• Amine Oxidase (Copper-Containing)

Topics

• Amine Oxidase (Copper-Containing) (blood, metabolism)
• Betacoronavirus
• Blood Coagulation Disorders (virology)
• COVID-19
• Cell Adhesion Molecules (blood, metabolism)
• Chemokine CX3CL1 (blood, metabolism)
• China
• Coronavirus Infections (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Intercellular Adhesion Molecule-1 (blood, metabolism)
• Male
• Middle Aged
• Pandemics
• Pneumonia, Viral (blood)
• Retrospective Studies
• SARS-CoV-2
• Vascular Cell Adhesion Molecule-1 (blood, metabolism)