Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: FINDINGS / RESULTS: In the sham-2NX group, after NPP injection, changes were observed in SBP (145.99 ± 3.6 mmHg), DBP (93.9 ± 3.87 mmHg), and HR (400.29 ± 12.78 bpm). In the captopril group, SBP and DBP had no significant changes, while HR increased significantly (P = 0.001). In the losartan group, SBP and DBP decreased (P = 0.001 and P = 0.000, respectively), while HR had no significant changes. In the 2NX group, after NPP injection, changes were denoted in SBP (127.89 ± 9.03 mmHg), DBP (65.86 ± 5.69 mmHg), and HR (333.35 ± 11.47 bpm). In addition, captopril injection increased DBP (P = 0.016) and HR (P = 0.036) in response to NPP injection, while losartan injection had no significant effects in this regard. CONCLUSION AND IMPLICATIONS:
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Authors | Akbar Pejhan, Ali Gohari, Mohammad Hassan Rakhshani, Peter C Papageorgiou, Muhammad Ibrar Mustafa, Rahim Golmohammadi |
Journal | Research in pharmaceutical sciences
(Res Pharm Sci)
Vol. 15
Issue 2
Pg. 174-181
(Apr 2020)
ISSN: 1735-5362 [Print] Iran |
PMID | 32582357
(Publication Type: Journal Article)
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Copyright | Copyright: © 2020 Research in Pharmaceutical Sciences. |