Immunohistochemical markers in the normal human epibulbar conjunctiva from fetus to adult.

Abstract

Monoclonal antibodies were used for the study of inflammatory cellular subtypes, Langerhans' cells, and major histocompatibility complex class II antigens on the epibulbar conjunctiva obtained from individuals ranging in age from fetus to the seventh decade to compile basic data for comparison with other inflammatory and proliferative conjunctival diseases. In the fetal conjunctiva, there were significantly fewer T cells and Langerhans' cells than in adult conjunctiva. In the adult conjunctiva, a mild T-cell infiltration was observed. Expression of HLA-DQ in the 20- to 50-year-old age group was significantly lower compared with fetal and other age groups.

• Authors: C C Chan, R B Nussenblatt, M Ni, S Li, W Mao
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 106 Issue 2 Pg. 215-7 (Feb 1988) ISSN: 0003-9950 [Print] United States
• PMID: 3257690 (Publication Type: Journal Article)

Chemical References

• Antigens, Differentiation
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Surface
• HLA Antigens
• HLA-DQ Antigens
• HLA-DR Antigens

Topics

• Adolescent
• Adult
• Aged
• Antigens, Differentiation (analysis)
• Antigens, Differentiation, T-Lymphocyte (analysis)
• Antigens, Surface (analysis)
• Child
• Child, Preschool
• Conjunctiva (immunology)
• Fetus (immunology)
• HLA Antigens (analysis)
• HLA-DQ Antigens (analysis)
• HLA-DR Antigens (analysis)
• Humans
• Infant
• Langerhans Cells (immunology)
• Macrophages (immunology)
• Middle Aged