Neuroleptic malignant syndrome in striatonigral degeneration.

Abstract

A case of probable neuroleptic malignant syndrome (NMS) complicating L-dopa withdrawal in striatonigral degeneration is described. This case suggests that the hyperthermia of NMS is due to peripheral heat production associated with severe muscular rigidity secondary to withdrawal of striatal dopamine drive, rather than being centrally mediated by the hypothalamus, which is not involved in striatonigral degeneration.

• Authors: W R Gibb
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 153 Pg. 254-5 (Aug 1988) ISSN: 0007-1250 [Print] England
• PMID: 3255444 (Publication Type: Case Reports, Journal Article)

Chemical References

• Levodopa

Topics

• Aged
• Corpus Striatum (pathology)
• Female
• Humans
• Levodopa (adverse effects)
• Neuroleptic Malignant Syndrome (etiology)
• Parkinson Disease (pathology)
• Substance Withdrawal Syndrome
• Substantia Nigra (pathology)