Role of γδT cells in liver diseases and its relationship with intestinal microbiota.

Abstract

γδT cells are unconventional T lymphocytes that bridge innate and adaptive immunity. Based on the composition of T cell receptor and the cytokines produced, γδT cells can be divided into diverse subsets that may be present at different locations, including the liver, epithelial layer of the gut, the dermis and so on. Many of these cells perform specific functions in liver diseases, such as viral hepatitis, autoimmune liver diseases, non-alcoholic fatty liver disease, liver cirrhosis and liver cancers. In this review, we discuss the distribution, subsets, functions of γδT cells and the relationship between the microbiota and γδT cells in common hepatic diseases. As γδT cells have been used to cure hematological and solid tumors, we are interested in γδT cell-based immunotherapies to treat liver diseases.

• Authors: Qi-Hui Zhou, Feng-Tian Wu, Lan-Tian Pang, Tian-Bao Zhang, Zhi Chen
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 26 Issue 20 Pg. 2559-2569 (May 28 2020) ISSN: 2219-2840 [Electronic] United States
• PMID: 32523311 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

Topics

• Animals
• Disease Models, Animal
• Gastrointestinal Microbiome (immunology)
• Humans
• Immunotherapy (methods)
• Intestinal Mucosa (immunology, microbiology)
• Intraepithelial Lymphocytes (immunology, transplantation)
• Liver (immunology, pathology)
• Liver Diseases (immunology, microbiology, pathology, therapy)