Chelator-induced enhancement of 67Ga tumour imaging: comparison of desferrioxamine with N,N'-ethylene-bis[2-hydroxy-5-carboxyphenylglycine].

Abstract

Intravenous injection of the gallium chelating agents, N,N'-ethylene bis[2-hydroxy-5-carboxyphenyl-glycine], (COOH-EHPG), or desferrioxamine (DFO) after gallium-67 (67Ga) injection, improved tumour/non-tumour tissue uptake ratios in mice bearing the EMT-6 sarcoma. Six hours post injection of gallium and 2 h post chelator, COOH-EHPG enhanced the tumour/blood ratios by an order of magnitude compared to untreated controls, whereas DFO increased the ratios three-fold. Twenty two hours post gallium and 2 h post chelator, the increases in ratios compared to controls were seven-fold for COOH-EHPG and two-fold for DFO. The study thus demonstrated the superior ability of COOH-EHPG for the enhancement of 67Ga tumour/blood ratios compared with DFO.

• Authors: F C Hunt
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 15 Issue 6 Pg. 651-7 ( 1988) ISSN: 0883-2897 [Print] England
• PMID: 3251899 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chelating Agents
• Citrates
• Ethylenediamines
• ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid)
• Citric Acid
• Deferoxamine

Topics

• Animals
• Chelating Agents (pharmacology)
• Citrates (metabolism)
• Citric Acid
• Deferoxamine (pharmacology)
• Ethylenediamines (pharmacology)
• Leukemia, Lymphoid (diagnostic imaging)
• Mammary Neoplasms, Experimental (diagnostic imaging)
• Mice
• Mice, Inbred BALB C
• Radionuclide Imaging
• Tissue Distribution