Laser Interstitial Thermal Therapy in the treatment of brain metastases and radiation necrosis.

Abstract

Stereotactic Radiosurgery has become the main treatment for patients with limited number of brain metastases (BM). Recently, with the increasing use of this modality, there is a growth in recurrence cases. Recurrence after radiation therapy can be divided in changes favoring either tumor recurrence or radiation necrosis (RN). Laser Interstitial Thermal Therapy (LITT) is minimally invasive treatment modality that has been used to treat primary and metastatic brain tumors. When associated with real-time thermometry using Magnetic Resonance Imaging, the extent of ablation can be controlled to provide maximum coverage and avoid eloquent areas. The objective of this study was to investigate the use of LITT in the treatment of BM. An extensive review of the relevant literature was conducted and the outcome results are discussed. There is an emphasis on safety and local control rate of patients treated with this modality. The findings of our study suggest that LITT is a viable safe technique to treat recurrent BM, especially in patients with deep-seated lesions where surgical resection is not an option.

• Authors: Dhiego Chaves de Almeida Bastos, Jeffrey Weinberg, Vinodh A Kumar, David T Fuentes, Jason Stafford, Jing Li, Ganesh Rao, Sujit S Prabhu
• Journal: Cancer letters (Cancer Lett) Vol. 489 Pg. 9-18 (10 01 2020) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 32504657 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Topics

• Brain Neoplasms (secondary, therapy)
• Humans
• Laser Therapy (methods)
• Necrosis (etiology)
• Radiation Injuries (etiology, therapy)
• Radiosurgery (adverse effects)