The efficacy of
piroxicam was tested on the model of immunologic, experimental
inflammation of the uveal tract. The
inflammation of the anterior part of the eyeball was provoked in rabbits by the method of Böcke. Intensity of
choroiditis was evaluated after second administration of homologous
antigen. The preparation investigated was given in the doses 5 and 15 mg/kg; behavior of the inflammatory indices was observed in the aqueous humor (
protein,
seromucoid,
sialic acid, proteolytic activity,
PGE2). Additionally, the changes within the anterior chamber and the iris were examined biomicroscopically. It was observed that relatively to the doses applied,
piroxicam suppressed the intensity of
inflammation evaluated by both biochemical as well as biomicroscopic indices. A substantial fall in the level of
protein,
seromucoid and
sialic acid was reported in the aqueous humor; proteolytic activity as well as
PGE2 normally absent under physiological conditions, were observed to subside. Biomicroscopically,
piroxicam suppressed
protein, precipitating exudate and decreased the number of morphotic elements in the aqueous humor. Moreover, it reduced the intensity of
hyperemia of the iris and caused the pupilary dilatation. The results in this report demonstrate that
piroxicam as nonsteroid, antiinflammatory
drug of the prolonged activity, may be successfully used as an ophthalmic preparation substituting the
steroid drugs.