Abstract |
The rate of collagen deposition in implanted polytetrafluoroethylene ( PTFE) tubing in non-diabetic and streptozotocin-induced (STZ) diabetic mice was measured during 14 days post-wounding. At the time of implantation, test groups received injections of either Quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl) ethylenediamine], glucan, or buffer in an area adjacent to the wound site. The accumulation of collagen in the implants of Quadrol-treated non-diabetic animals was more than 200% above control on days 8 to 11 and was 50% above control on day 14. In Quadrol-treated STZ-diabetic mice, the collagen accumulation gradually increased from 50% above control on day 8 to 200% above control on day 14. Treatment with glucan increased the collagen accumulation in normal mice 200 to 300% above control from days 8 to 11 respectively and then 30% above control on day 14. Collagen accumulation in the implants of the glucan-treated STZ-diabetic mice was similar to the control group. These results indicate that Quadrol promotes in vivo collagen synthesis and that Quadrol may be effective as a stimulator of wound healing in diabetic and non-diabetic animals.
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Authors | M V Bhide, M J Dunphy, N Mirkopulos, D J Smith |
Journal | Immunopharmacology and immunotoxicology
(Immunopharmacol Immunotoxicol)
Vol. 10
Issue 4
Pg. 513-22
( 1988)
ISSN: 0892-3973 [Print] England |
PMID | 3246540
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ethylenediamines
- 1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol
- Collagen
- Hydroxyproline
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Topics |
- Animals
- Collagen
(biosynthesis)
- Diabetes Mellitus, Experimental
(metabolism)
- Ethylenediamines
(pharmacology)
- Female
- Hydroxyproline
(analysis)
- Mice
- Mice, Inbred BALB C
- Prostheses and Implants
- Time Factors
- Wound Healing
(drug effects)
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