Consensus Statement on Proton Therapy in Mesothelioma.
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| Abstract | PURPOSE:
Radiation therapy for mesothelioma remains challenging, as normal tissue toxicity limits the amount of radiation that can be safely delivered to the pleural surfaces, especially radiation dose to the contralateral lung. The physical properties of proton therapy result in better sparing of normal tissues when treating the pleura, both in the postpneumonectomy setting and the lung-intact setting. Compared with photon radiation, there are dramatic reductions in dose to the contralateral lung, heart, liver, kidneys, and stomach. However, the tissue heterogeneity in the thorax, organ motion, and potential for changing anatomy during the treatment course all present challenges to optimal irradiation with protons. METHODS: The clinical data underlying proton therapy in mesothelioma are reviewed here, including indications, advantages, and limitations. RESULTS: The Particle Therapy Cooperative Group Thoracic Subcommittee task group provides specific guidelines for the use of proton therapy for mesothelioma. CONCLUSIONS: This consensus report can be used to guide clinical practice, insurance approval, and future research.
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| Authors | Jing Zeng, Shahed N Badiyan, Yolanda I Garces, Tony Wong, Xiaodong Zhang, Charles B Simone 2nd, Joe Y Chang, Antje C Knopf, Shinichiro Mori, Hiromitsu Iwata, Arturs Meijers, Heng Li, Martin Bues, Wei Liu, Steven E Schild, Ramesh Rengan, International Particle Therapy Cooperative Group Thoracic Subcommittee |
| Journal | Practical radiation oncology (Pract Radiat Oncol) 2021 Mar-Apr Vol. 11 Issue 2 Pg. 119-133 ISSN: 1879-8519 [Electronic] United States |
| PMID | 32461036 (Publication Type: Journal Article, Review) |
| Copyright | Copyright © 2020 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved. |
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