Gender-specific associations of CD36 polymorphisms with the lipid profile and susceptibility to premature multi-vessel coronary artery heart disease in the Northern Han Chinese.

Abstract

BACKGROUND:

The aim of the present study was to detect potential gender-specific associations between some common CD36 single nucleotide polymorphisms (SNPs) and the lipid profile, as well as the susceptibility to premature multi-vessel coronary artery heart disease (CHD) in the Han population of Northern China.

METHODS:

A systematic three-step study process was employed to detect associations between CD36 gene variants and blood lipid profiles, as well as premature multi-vessel CHD in a gender-specific manner.

RESULTS:

The current study documented the following novel findings: (I) the full population-based association study in 329 Northern Han Chinese showed that four common CD36 polymorphisms were significantly related to extreme lipid profiles, with statistically significant effects based on gender interactions (rs1049673: P = 0.001; rs7755: P = 0.008; rs3211956: P = 0.034; and rs3173798: P = 0.004); (ii) these statistically significant effects could be decomposed into statistically significant atherogenic effects in males, but non-significant non-atherogenic effects in females; (iii) the results of logistic regression analysis indicated that current smoking status, low density lipoprotein cholesterol (LDL-C) levels, and type-2 diabetes were independent risk factors for premature multi-vessel CHD phenotype (P < 0.0001).

CONCLUSIONS:

Four common CD36 polymorphisms (rs1049673, rs7755, rs3211956, and rs3173798) were identified to be significantly associated with extreme lipid profiles and had statistically opposite gender-specific clinical lipid profile effects. Thus, the 3'-untranslated regions (3'-UTR) CD36 SNPs could be a novel target for metabolic abnormalities in males of the Han nationality from Northern China.

• Authors: Yaqin Du, Kangyin Chen, Enzhao Liu, Xuewen Wang, Feixue Li, Tong Liu, Xintian Zheng, Guangping Li, Jingjin Che
• Journal: Gene (Gene) Vol. 753 Pg. 144806 (Aug 30 2020) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 32461018 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• CD36 Antigens
• CD36 protein, human
• Lipids

Topics

• Adult
• Asian People (genetics)
• Atherosclerosis (blood, genetics, pathology)
• CD36 Antigens (genetics)
• Case-Control Studies
• China (epidemiology)
• Coronary Artery Disease (blood, epidemiology, genetics, pathology)
• Coronary Vessels (pathology)
• Ethnicity (genetics)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lipids (blood, genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Risk Factors
• Sex Characteristics