Five-year results of viscotrabeculotomy versus conventional trabeculotomy in primary congenital glaucoma: A randomized controlled study.

Abstract

PURPOSE:

To assess the long-term results of viscotrabeculotomy in infants with primary congenital glaucoma and to compare its outcome with conventional trabeculotomy.

PATIENTS AND METHODS:

A prospective randomized comparative study included infants with primary congenital glaucoma younger than 2 years. Patients were divided into two groups: viscotrabeculotomy group and conventional trabeculotomy group. Preoperative and postoperative intraocular pressures, corneal diameter, intraoperative and postoperative complications, and success rates were compared between two groups. All the patients were followed up for 5 years.

RESULTS:

The study included 154 eyes of 92 infants distributed randomly among the two groups; 78 and 76 eyes in viscotrabeculotomy and conventional trabeculotomy groups, respectively. In both groups, there was a statistically significant intraocular pressure reduction at all time points of the follow-up periods compared to the preoperative values (p < 0.0001). At 5 years, viscotrabeculotomy group showed significant reduction of the mean postoperative intraocular pressure (49.47%) than conventional trabeculotomy group (48.64%) (p < 0.0001). Intraocular pressure was statistically lower in viscotrabeculotomy starting from 12th month and till the end of the follow-up. At 5 years, the total success rate of viscotrabeculotomy group was 89.74% compared to 85.53% in conventional trabeculotomy group without significant difference (p = 0.487). The postoperative mean values of the cup/disk ratio in viscotrabeculotomy group showed statistically lower values compared to conventional trabeculotomy group (p = 0.019). Postoperative hyphema was statistically higher in conventional trabeculotomy group (p < 0.0001). All eyes that underwent a reoperation before 5 years follow-up were excluded from the statistical workup of the study after reoperation, except for calculation of success/failure.

CONCLUSION:

Viscotrabeculotomy and conventional trabeculotomy proved to be effective in cases of primary congenital glaucoma. Viscotrabeculotomy appeared to have prolonged stability in controlling the intraocular pressure with higher success rates and lower complications.

• Authors: Ahmed S Elwehidy, Sherein M Hagras, Nader Bayoumi, Ayman E AbdelGhafar, Amani E Badawi
• Journal: European journal of ophthalmology (Eur J Ophthalmol) Vol. 31 Issue 2 Pg. 786-795 (Mar 2021) ISSN: 1724-6016 [Electronic] United States
• PMID: 32450720 (Publication Type: Journal Article, Randomized Controlled Trial)

Topics

• Female
• Glaucoma (diagnosis, physiopathology, surgery)
• Humans
• Infant
• Intraocular Pressure (physiology)
• Male
• Postoperative Complications
• Prospective Studies
• Tonometry, Ocular
• Trabeculectomy (methods)
• Treatment Outcome