SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review.

Abstract

INTRODUCTION:

Coronavirus has been responsible for several virus outbreaks since 2003, caused by SARS-CoV-1, MERS-CoV, and currently SARS-CoV-2 (COVID-19), the causative agent of coronavirus disease in 2019. COVID-19 has become a global public health emergency because of its high virulence and mortality capacity. This patent review aims to provide an overview of the patents that present possible treatments for SARS-CoV-1, SARS-CoV-2 and MERS-CoV.

AREAS COVERED:

To treat SARS, MERS and SARS-CoV-2, researchers have filed patents for a number of therapeutic agents. Most of the treatments found were protease inhibitors aimed at proteases such as PLpro, 3 CLpro, RNA helicase, and Spike protein, or used monoclonal antibodies and interferons. In addition, the use of Chinese folk medicine and its multitude of medicinal plants with strong antiviral properties was reinforced. Thus, these therapies used in previous epidemics can serve as an aid in the new pandemic by SARS-CoV-2 and be a starting point for new treatments.

EXPERT OPINION:

The various antiviral alternatives presented in this review offer therapeutic options to fight coronavirus infections. If shown to be effective, these drugs may be extremely important in the current pandemic.

• Authors: José Adão Carvalho Nascimento Junior, Anamaria Mendonça Santos, Lucindo José Quintans-Júnior, Cristiani Isabel Banderó Walker, Lysandro Pinto Borges, Mairim Russo Serafini
• Journal: Expert opinion on therapeutic patents (Expert Opin Ther Pat) Vol. 30 Issue 8 Pg. 567-579 (Aug 2020) ISSN: 1744-7674 [Electronic] England
• PMID: 32429703 (Publication Type: Journal Article, Review)

Chemical References

• Antiviral Agents

Topics

• Animals
• Antiviral Agents (adverse effects, therapeutic use)
• Betacoronavirus (drug effects, pathogenicity)
• COVID-19
• Coronavirus Infections (diagnosis, drug therapy, virology)
• Drug Development
• Drug Discovery
• Host-Pathogen Interactions
• Humans
• Middle East Respiratory Syndrome Coronavirus (drug effects, pathogenicity)
• Pandemics
• Patents as Topic
• Pneumonia, Viral (diagnosis, drug therapy, virology)
• Severe acute respiratory syndrome-related coronavirus (drug effects, pathogenicity)
• SARS-CoV-2
• Severe Acute Respiratory Syndrome (diagnosis, drug therapy, virology)
• Treatment Outcome
• COVID-19 Drug Treatment