Metabolic regulation as a control for lipid disorders. I. Influence of (--)-hydroxycitrate on experimentally induced obesity in the rodent.

Abstract

The feasibility of treating obesity by metabolic regulation has been explored in this study by examining the effect of (--)-hydroxycitrate on three types of experimentally induced obesity in the rodent.(--)-Hydroxycitrate was utilized because it depressed fatty acid and cholesterol synthesis in vivo through its activity as a potent competitive inhibitor of APT citrate lyase. In all models, the mature rat, the goldthioglucose-induced obese mouse, and the ventromedial hypothalmic lesioned obese rat, food intake and body weight gain were reduced signficantly by the chronic oral administration of a nontoxic dose of (--)-hydroxcitrate. Body composition analyses of mature rats treated with (--)-hydroxycitrate demonstrated a significant depression of body lipid levels and an unaltered body protein content. However, a citrate administration produced no significant effects on weight gain, food intake, or body lipid or protein levels when compared to controls.

• Authors: C Sullivan, J Triscari
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 30 Issue 5 Pg. 767-76 (May 1977) ISSN: 0002-9165 [Print] United States
• PMID: 324261 (Publication Type: Journal Article)

Chemical References

• Appetite Depressants
• Citrates
• Proteins
• Aurothioglucose

Topics

• Animals
• Appetite Depressants (therapeutic use)
• Aurothioglucose
• Body Composition
• Body Weight (drug effects)
• Citrates (therapeutic use)
• Diet
• Disease Models, Animal
• Female
• Hypothalamus, Middle (physiology, surgery)
• Lipid Metabolism
• Mice
• Mice, Inbred CBA
• Obesity (chemically induced, drug therapy)
• Proteins (metabolism)
• Rats
• Structure-Activity Relationship