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Effect of calcitonin on hepatic drug metabolism.

Abstract
A single dose of calcitonin (150 mIU/100 g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver.
AuthorsA F Godinho, G J Cavalcante, M G Machado, T F Faria, T C Gil, R B Coutinho, C Garcia
JournalBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 21 Issue 4 Pg. 851-3 ( 1988) ISSN: 0100-879X [Print] Brazil
PMID3240382 (Publication Type: Journal Article)
Chemical References
  • salmon calcitonin
  • Calcitonin
  • Mixed Function Oxygenases
  • Aminopyrine N-Demethylase
  • Pentobarbital
  • Antipyrine
Topics
  • Aminopyrine N-Demethylase (metabolism)
  • Animals
  • Antipyrine (metabolism)
  • Calcitonin (pharmacology)
  • Liver (enzymology)
  • Male
  • Mixed Function Oxygenases (metabolism)
  • Pentobarbital (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Sleep (drug effects)

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