Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Abstract

BACKGROUND:

Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation "HTOR-091516" containing Curcuma longa, Triphala and honey were evaluated for the treatment of OM.

AIM:

The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.

MATERIALS AND METHODS:

The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.

RESULTS:

The in vitro safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.

CONCLUSION:

The present data indicate that HTOR-091516 is effective in the treatment of OM.

• Authors: Suryakanth Dattatreya Anturlikar, Mohammed Mukhram Azeemuddin, Sandeep Varma, Onkaramurthy Mallappa, Dilip Niranjan, Ashok Basti Krishnaiah, Shruthi Manjunath Hegde, Mohamed Rafiq, Rangesh Paramesh
• Journal: Ayu (Ayu) 2019 Apr-Jun Vol. 40 Issue 2 Pg. 127-133 ISSN: 0974-8520 [Print] India
• PMID: 32398914 (Publication Type: Journal Article)
• Copyright: Copyright: © 2020 AYU (An International Quarterly Journal of Research in Ayurveda).