Abstract | OBJECTIVE: RESULTS: The CML immunoreactivity in the endothelial cells and intima of arterial walls in the interstitium of ventricular muscles was significantly stronger in the aged group, compatible with the progression of atherosclerosis. The blood level of NT-proBNP, a known useful marker for heart failure, had the positive correlation with the CML immunoreactivity. The degree of fibrosis, heart weights and the histories of hypertension and hyperlipidemia showed positive correlations with the CML immunoreactivity. Our results show the novel positive correlation between the CML immunohistochemistry in the heart vessels and heart conditions, and its future usefulness in the cardiovascular evaluation in histopathology.
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Authors | Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai, Tadashi Nishio |
Journal | BMC research notes
(BMC Res Notes)
Vol. 13
Issue 1
Pg. 239
(May 12 2020)
ISSN: 1756-0500 [Electronic] England |
PMID | 32398121
(Publication Type: Journal Article)
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Chemical References |
- Glycation End Products, Advanced
- Natriuretic Peptides
- N(6)-carboxymethyllysine
- Lysine
|
Topics |
- Adult
- Aged
- Atherosclerosis
(metabolism, pathology)
- Atrial Remodeling
- Autopsy
- Coronary Vessels
(metabolism, pathology)
- Female
- Fibrosis
(metabolism, pathology)
- Forensic Pathology
- Glycation End Products, Advanced
(metabolism)
- Humans
- Immunohistochemistry
- Lysine
(analogs & derivatives, metabolism)
- Male
- Middle Aged
- Myocardial Infarction
(metabolism, pathology)
- Myocardial Ischemia
(metabolism, pathology)
- Natriuretic Peptides
(metabolism)
- Young Adult
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