Scanning electron microscopy of human urine and purified Tamm-Horsfall's glycoprotein.

Abstract

Dialyzed and dehydrated human urine and purified Tamm-Horsfall's glycoprotein revealed similar morphology by scanning electron microscopy. Single filaments, with diameters between 15-45 nm, splitting off and merging with thicker fibers at irregular intervals made up a three-dimensional meshwork with submicrometer pores. The resulting "fishing net" is capable of trapping microorganisms and may facilitate their elimination from the urinary tract by micturition. Tamm-Horsfall's glycoprotein may accordingly be a factor protecting against urinary tract infections.

• Authors: R Bjugn, P R Flood
• Journal: Scandinavian journal of urology and nephrology (Scand J Urol Nephrol) Vol. 22 Issue 4 Pg. 313-5 ( 1988) ISSN: 0036-5599 [Print] England
• PMID: 3238339 (Publication Type: Journal Article)

Chemical References

• Mucoproteins
• UMOD protein, human
• Uromodulin

Topics

• Humans
• Male
• Microscopy, Electron, Scanning
• Mucoproteins (ultrastructure)
• Urine
• Uromodulin