Cutaneous manifestations of defective host defenses.

Abstract

Those caring for children should recognize that cutaneous findings are common in children with host defense defects. Atopic dermatitis, recurrent or persistent pyodermas, candidiasis and lupus-like syndromes, should signal the possibility of host defense deficiencies. Particularly the findings of atopic dermatitis and recurrent skin abscesses should alert the clinician to determine serum IgE levels and neutrophil chemotaxis in such patients. The triad of generalized seborrheic dermatitis, failure to thrive, and diarrhea in an infant should bring to mind Leiner disease or severe combined immunodeficiency disease.

• Authors: W L Weston
• Journal: Pediatric clinics of North America (Pediatr Clin North Am) Vol. 24 Issue 2 Pg. 395-407 (May 1977) ISSN: 0031-3955 [Print] United States
• PMID: 323807 (Publication Type: Journal Article, Review)

Chemical References

• Immunoglobulin E

Topics

• Abscess (etiology)
• Candidiasis, Cutaneous (etiology)
• Chemotaxis, Leukocyte
• Child
• Dermatitis (immunology)
• Dermatitis, Atopic (etiology)
• Humans
• Hypergammaglobulinemia (complications)
• Immunoglobulin E
• Immunologic Deficiency Syndromes (complications)
• Infant
• Lupus Erythematosus, Systemic (etiology)
• Neutrophils (immunology)
• Skin (immunology)
• Skin Diseases (etiology, immunology)