Study on the Effect of Lidocaine in the Cuff for Endotracheal Tube in Vitro and in Vivo.

Abstract

OBJECTIVE:

The purpose of this research was to investigate the effectiveness on postoperative pharyngalgia of filling the endotracheal catheter (ETC) cuffs with air, double distilled water, 2% lidocaine hydrochloride, and 1.73% lidocaine carbonate.

METHODS:

A group of 80 female patients were divided into 4 groups randomly. The ETC cuffs were filled with air (Group A), double distilled water (Group B), 2% lidocaine hydrochloride (Group C), and 1.73% lidocaine carbonate (Group D) after endotracheal intubation in corresponding patients. Sore throat, hoarseness, bucking, perioperative hemodynamic changes were examined in all participants.

RESULTS:

The Group D had significantly less severity of POST (P < 0.05), postoperative hoarseness (P < 0.05) and bucking on emergence from general anesthesia (P < 0.01) than patients from other groups. The Group D reported significantly less hemodynamic changes after extubation 1, 5, 10 minutes (P < 0.05).

CONCLUSION:

Lidocaine carbonate injected into the ETC cuffs decreased the severity of postoperative pharyngalgia, postoperative hoarseness and bucking on emergence from general anesthesia.

• Authors: Biming Zhan, Zhiping Song, Shibiao Chen, Jia Min, Yang Zhang
• Journal: The Journal of craniofacial surgery (J Craniofac Surg) Vol. 31 Issue 6 Pg. 1721-1723 (Sep 2020) ISSN: 1536-3732 [Electronic] United States
• PMID: 32371705 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Lidocaine

Topics

• Anesthesia, General
• Female
• Hoarseness (etiology)
• Humans
• Intubation, Intratracheal
• Lidocaine (adverse effects, pharmacology)
• Pharyngitis (etiology)
• Postoperative Complications
• Postoperative Period