Gadolinium-Rose Bengal Coordination Polymer Nanodots for MR-/Fluorescence-Image-Guided Radiation and Photodynamic Therapy.

Abstract

Combination therapy based on nanomedicine has gained momentum in oncology in recent years, offering superior safety and efficacy over monotherapies. It is critical to design theranostics that are composed of imaging and therapeutic agents already approved. Herein, gadolinium (Gd)-rose bengal coordination polymer nanodots (GRDs) are reported. The GRDs exhibit a unique absorption property and 7.7-fold luminescence enhancement, as well as a 1.9-fold increase in singlet oxygen generation efficiency over free rose bengal. Meanwhile, GRDs exhibit a twofold increase in r1 relaxivity over gadopentetic acid (Gd-DTPA) and have better X-ray absorption ability than rose bengal alone. These excellent properties of the GRDs are verified both in vitro and in vivo. The combination of photodynamic therapy (PDT) and radiation therapy (RT) more significantly inhibits tumor growth than monotherapies (i.e., PDT or RT). This work offers a new route to designing and synthesizing Gd-based nanotheranostics for image-guided cancer therapy.

• Authors: Wenjing Sun, Li Luo, Yushuo Feng, Yuwei Qiu, Changrong Shi, Shanshan Meng, Xiaoyuan Chen, Hongmin Chen
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 32 Issue 23 Pg. e2000377 (Jun 2020) ISSN: 1521-4095 [Electronic] Germany
• PMID: 32363649 (Publication Type: Journal Article)
• Copyright: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Coordination Complexes
• Polymers
• Rose Bengal
• Gadolinium

Topics

• Animals
• Cell Line, Tumor
• Coordination Complexes (chemistry)
• Gadolinium (chemistry)
• Magnetic Resonance Imaging
• Mice
• Nanomedicine
• Nanoparticles (chemistry)
• Optical Imaging
• Photochemotherapy (methods)
• Polymers (chemistry, therapeutic use)
• Radiotherapy, Image-Guided (methods)
• Rose Bengal (chemistry)