A nuclear DNA study of uterine cervical dysplasia with reference to its prognostic significance.

Abstract

To further define the nuclear DNA content of uterine cervical dysplasia and its relationship to prognosis and epidemiological features, a retrospective study using Papanicolaou stained cytological specimen and TICAS was undertaken. 1. Dysplasia patients was common among young females who had a background of low age first pregnancy, multiple Gravidity-Parity, the complication of inflammation and the use of hormonal contraceptives and progressed rapidly. It is recommended that a test should be repeated within 2 to 3 months regardless of the severity of the dysplasia and patients should be followed up for at least 2.5 to 3 years. 2. The DNA histograms were classified into 3 types (A,B and C): Type C, which had the stem line in an aneuploidy area, showed more severe dysplastic cases. This may be due to the proliferation rate and significant alternation in the chromosomes and mitoses. Nuclear DNA analysis using TICAS and Papanicolaou stained cytological material could discriminate between the progressive group and the persistent or regressive group. In addition, the mean nuclear area might be the best indicator of prognosis in uterine cervical dysplasia.

• Authors: K Yokosuka, K Sato, T Izutsu, T Kagabu, I Nishiya, G L Wied
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 40 Issue 11 Pg. 1760-6 (Nov 1988) ISSN: 0300-9165 [Print] Japan
• PMID: 3235889 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Adolescent
• Adult
• Aneuploidy
• Cell Nucleus (analysis)
• DNA, Neoplasm (analysis, genetics)
• Female
• Follow-Up Studies
• Humans
• Papanicolaou Test
• Prognosis
• Retrospective Studies
• Risk Factors
• Uterine Cervical Dysplasia (analysis, genetics)
• Vaginal Smears