Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model.

Abstract	A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
Authors	G Rowlinson, G Paganelli, D Snook, A A Epenetos
Journal	The International journal of biological markers (Int J Biol Markers) 1988 Oct-Dec Vol. 3 Issue 4 Pg. 259-64 ISSN: 0393-6155 [Print] United States
PMID	3235854 (Publication Type: Journal Article)
Chemical References	Antibodies, Monoclonal Carcinoembryonic Antigen Immunoglobulin Fab Fragments
Topics	Adenocarcinoma (diagnostic imaging) Animals Antibodies, Monoclonal Antibody Specificity Carcinoembryonic Antigen (immunology) Cell Line Colonic Neoplasms (diagnostic imaging) Female Humans Immunoglobulin Fab Fragments Mice Mice, Nude Neoplasm Transplantation Radionuclide Imaging

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