Effect of bilateral salpingo-oophorectomy on the overall survival of premenopausal patients with stage I low-grade endometrial stromal sarcoma; a National Cancer Database analysis.

Abstract

OBJECTIVES:

Investigate the prevalence of bilateral salpingo-oophorectomy (BSO) for women ≤50 years with early stage low-grade endometrial stromal sarcoma (LGESS) and its impact on overall survival (OS).

METHODS:

Women ≤50 years, diagnosed with stage I LGESS and managed with hysterectomy between 2004 and 2015 were identified from the National Cancer Database. Patient demographics were recorded and compared with the chi-square test. OS for patients diagnosed between 2004 and 2014 with at least one month of follow-up was assessed using Kaplan-Meier curves, and compared with the log-rank test.

RESULTS:

A total 743 patients with a median age of 44 years met the inclusion criteria. Use of radiatiotherapy (9%), chemotherapy (0.8%) and hormonal therapy (11%) was infrequent. BSO was performed in 541 (72.8%) patients. Patients who had ovarian preservation (OP) were younger (median age 43 vs 45 years, p < 0.001), less likely to have comorbidities (6.9% vs 12.4%, p = 0.034), or undergo LND (30.7% vs 44.4%, p = 0.001). There were no differences between the two groups in terms of substage or patient race. Five year OS rates for patients who did (n = 490) and did not (n = 191) undergo BSO were 96.2% and 97.1% and there was no difference in OS, p = 0.50. Even after controlling for presence of comorbidities performance of BSO was not associated with better survival (HR: 1.28, 95% CI: 0.51, 3.19).

CONCLUSIONS:

Ovarian function was preserved in approximately one third of women ≤50 years with stage I LGESS with no clear detriment to overall survival. As BSO is associated with long term health effects in this patient population OP could be considered in selected women with stage I LGESS.

• Authors: Dimitrios Nasioudis, Spyridon A Mastroyannis, Nawar A Latif, Emily M Ko, Ashley F Haggerty, Sarah H Kim, Mark A Morgan, Robert L Giuntoli 2nd
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 157 Issue 3 Pg. 634-638 (06 2020) ISSN: 1095-6859 [Electronic] United States
• PMID: 32354469 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Databases, Factual
• Female
• Humans
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Retrospective Studies
• Salpingo-oophorectomy (methods)
• Sarcoma, Endometrial Stromal (mortality, surgery)
• Survival Analysis
• Young Adult