Blood and plasma viscosity after acipimox treatment in hypertriglyceridemic patients.

Abstract

Acipimox, a nicotinic acid analog, is known to reduce the plasma lipid concentration in hyperlipidemic patients. In a study to check whether the drug improved hemo-rheological parameters, 21 patients (17 M, 4 F) with asymptomatic hypertriglyceridemia were treated with acipimox (250 b.i.d.) for 30 days. Plasma lipid concentrations were measured before and after therapy, together with blood and plasma viscosity. Mean plasma cholesterol and triglyceride levels decreased from 234 +/- 51 (SD) mg/dl to 202 +/- 53 mg/dl (p less than 0.01) and from 515 +/- 231 mg/dl to 298 +/- 130 mg/dl (p less than 0.01) respectively. Blood viscosity decreased (p less than 0.05 and less than 0.01) (range of reduction 6-20%) at all shear rates examined (from 2.25 s-1 to 450 s-1); plasma viscosity was significantly reduced only at lower shear rates (2.25 and 4.50 s-1). Changes in blood and plasma viscosity after acipimox treatment were not related to changes in plasma triglycerides. Acipimox seems to act beneficially on hemo-rheological parameters, independently of its hypolipidemic effect and could be usefully prescribed to patients with clinical signs of arteriosclerosis.

• Authors: S Montefusco, G Iannaci, A Gnasso, C Cortese, F Lamenza, A Postiglione
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 26 Issue 10 Pg. 492-4 (Oct 1988) ISSN: 0174-4879 [Print] Germany
• PMID: 3235215 (Publication Type: Journal Article)

Chemical References

• Lipids
• Pyrazines
• Triglycerides
• Cholesterol
• acipimox

Topics

• Adolescent
• Adult
• Blood Viscosity (drug effects)
• Cholesterol (blood)
• Female
• Humans
• Hypertriglyceridemia (blood, drug therapy)
• Lipids (blood)
• Male
• Middle Aged
• Pyrazines (therapeutic use)
• Triglycerides (blood)