Abstract | OBJECTIVES: The purpose was to compare the effects of 3 different dose combinations of bupivacaine and sufentanil on the onset of analgesia and the occurrence of side effects. MATERIALS AND METHODS: One hundred sixty-nine pregnant women were randomly assigned to 3 groups: the B1S5 group received 0.1% bupivacaine+5 μg sufentanil in 15 mL; the B125S5 group received 0.125% bupivacaine+5 μg sufentanil in 15 mL; and the B1S10 group received 0.1% bupivacaine+10 μg sufentanil in 15 mL. The primary outcome was the analgesic onset time, and the secondary outcomes were mode of delivery, patient satisfaction, maternal and neonatal side effects ( pruritus, hypotension, sedation, motor block, decreased fetal heart rate, fever, and interference with breastfeeding). RESULTS: The median (inter-quartile range) time to achieve effective analgesia was significantly faster in the B125S5 group than in the B1S5 group (10 [11-14 {4-30}] min vs. 15 [17-20 {5-30}] min, P<0.001). There was no significant difference in the analgesia onset time between the B1S10 and B125S5 groups (10 [11-14 {4-30}] min vs. 12 [13-15 {3-30}] min, P=0.202). Pruritus, hypotension, motor block, maternal satisfaction, delivery mode, decreased fetal heart rate, total bupivacaine dose and breastfeeding scores were not significantly different among the 3 groups except the sufentanil dosage and incidence of mild drowsiness and fever (the B1S10 group had significantly higher fever than the other groups). DISCUSSION: The B125S5 combination may be superior to the B1S5 and B1S10 combinations as an initial dose for epidural analgesia to achieve rapid effective analgesia with minimal side effects.
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Authors | Tingting Wang, Yaojun Lu, Peiwen Zhou, Shaoqiang Huang, Xinhua Yu |
Journal | The Clinical journal of pain
(Clin J Pain)
Vol. 36
Issue 8
Pg. 612-617
(08 2020)
ISSN: 1536-5409 [Electronic] United States |
PMID | 32349005
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Anesthetics, Local
- Sufentanil
- Bupivacaine
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Topics |
- Analgesia, Epidural
(adverse effects)
- Analgesia, Obstetrical
(adverse effects)
- Analgesics, Opioid
- Anesthetics, Local
(adverse effects)
- Bupivacaine
(adverse effects)
- Double-Blind Method
- Female
- Humans
- Infant, Newborn
- Pregnancy
- Sufentanil
(adverse effects)
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