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Urinary bisphenol A and its interaction with ESR1 genetic polymorphism associated with non-small cell lung cancer: findings from a case-control study in Chinese population.

Abstract
Bisphenol A (BPA), a well-known endocrine disruptor, was reported to promote migration and invasion of lung cancer cells, but findings in human study is absent. A case-control study in Chinese population was conducted to evaluate the association between BPA exposure and non-small cell lung cancer (NSCLC), and explore the interaction between BPA exposure and estrogen-related genetic polymorphism on NSCLC. BPA concentrations were measured in urine samples using an UHPLC-MS method and rs2046210 in estrogen receptor α (ESR1) gene was genotyped by TaqMan genotyping system. Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the association analyses. As a result, 615 NSCLC cases and 615 healthy controls were enrolled from Wuhan, central China. The mean age was 58.0 (SD: 7.9) years old for controls and 59.2 (SD: 8.8) years old for cancer cases. The creatinine-adjusted BPA levels were significantly higher in NSCLC cases than that in healthy controls (median: 0.97 vs 0.73 μg/L, P < 0.001). Exposure to high levels of BPA was significantly associated with NSCLC (adjusted OR = 1.91, 95%CI: 1.39-2.62, P < 0.001 for the highest quartile). We also observed a shallow concave dose-response relationship about the overall association between BPA and NSCLC. Moreover, interaction analyses showed that BPA exposure interacted multiplicatively with rs2046210, with a marginal P value (P = 0.049), to contribute to NSCLC. In conclusion, exposure to high levels BPA may be associated with NSCLC and the relationship may be modified by genetic polymorphism in ESR1.
AuthorsJiaoyuan Li, Zhi Ji, Xia Luo, Ying Li, Peihong Yuan, Jieyi Long, Na Shen, Qing Lu, Qiang Zeng, Rong Zhong, Ying Shen, Liming Cheng
JournalChemosphere (Chemosphere) Vol. 254 Pg. 126835 (Sep 2020) ISSN: 1879-1298 [Electronic] England
PMID32348927 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Elsevier Ltd. All rights reserved.
Chemical References
  • Benzhydryl Compounds
  • ESR1 protein, human
  • Endocrine Disruptors
  • Estrogen Receptor alpha
  • Phenols
  • bisphenol A
Topics
  • Benzhydryl Compounds (urine)
  • Carcinoma, Non-Small-Cell Lung (epidemiology)
  • Case-Control Studies
  • Child
  • China (epidemiology)
  • Endocrine Disruptors (urine)
  • Environmental Exposure (statistics & numerical data)
  • Estrogen Receptor alpha (genetics)
  • Female
  • Humans
  • Logistic Models
  • Lung Neoplasms (epidemiology)
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenols (urine)
  • Polymorphism, Genetic

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