The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis.

Abstract

BACKGROUND:

The interleukin-12 (IL-12) family consists of four members, namely, IL-12, IL-23, IL-27, and IL-35. The aim of this study was to examine the expression of circulating IL-12, IL-23, IL-27, and IL-35 in hypertensive patients.

METHODS:

Blood samples were collected from hypertensive patients and nonhypertensive (control) subjects, and protein multifactorial monitor kits were used to measure the plasma IL-12, IL-23, IL-27, and IL-35 levels in each sample. In addition, all enrolled subjects underwent ambulatory blood pressure monitoring (ABPM) and vascular stiffness.

RESULTS:

Hypertensive patients exhibited higher IL-12, IL-23, and IL-27 levels and lower IL-35 levels than control subjects; IL-12, IL-23, and IL-27 levels were positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), while IL-35 levels were negatively correlated with SBP and DBP. IL-12, IL-23, and IL-27 levels gradually increased in patients with grade I, II, and III hypertension, while IL-35 levels gradually reduced. According to the ABPM results, hypertensive patients were divided into the dipper and nondipper hypertension groups; IL-12, IL-23, IL-27, and IL-35 levels showed no differences between the two groups, but IL-12, IL-23, and IL-27 levels in both groups increased compared with those in the control group, while IL-35 levels decreased. Additionally, the expression of these IL-12 family members was influenced by many clinical factors and was independently associated with the occurrence of carotid atherosclerotic plaques.

CONCLUSIONS:

The changes in IL-12, IL-23, IL-27, and IL-35 levels were not associated with the presence of the nondipper type but were closely associated with the development of carotid atherosclerotic plaque in hypertensive patients.

• Authors: Jing Ye, Yuan Wang, Zhen Wang, Ling Liu, Zicong Yang, Menglong Wang, Yao Xu, Di Ye, Jishou Zhang, Qi Zhou, Yingzhong Lin, Qingwei Ji, Jun Wan
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2020 Pg. 2369279 ( 2020) ISSN: 1466-1861 [Electronic] United States
• PMID: 32322161 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Jing Ye et al.

Chemical References

• Interleukin-23
• Interleukin-27
• Interleukins
• interleukin-35, human
• Interleukin-12

Topics

• Adult
• Aged
• Blood Pressure (physiology)
• Carotid Artery Diseases (blood, physiopathology)
• Female
• Humans
• Hypertension (blood, physiopathology)
• Interleukin-12 (blood)
• Interleukin-23 (blood)
• Interleukin-27 (blood)
• Interleukins (blood)
• Male
• Middle Aged