Polymorphonuclear leukocyte functions in psoriasis.

Abstract

Circulating polymorphonuclear leukocyte (CPMN) functions were studied in patients with widespread psoriasis as well as in persons with chronic alcoholic liver disease (CALD), paracoccidioidomycosis, diverse granulomatous diseases, and normal individuals. We were unable to find stimulation or increase in CPMN functions in patients with psoriasis compared to normal individuals. Leukocytes from individuals with CALD had a lowering of their metabolic activation, chemotaxis, random movement, and adherence. CPMNs from patients with paracoccidioidomycosis showed a significant deficiency in their ability to digest Paracoccidioides brasiliensis. Our results are against the concept that functions of circulating PMNs are stimulated in psoriatics.

• Authors: M Goihman-Yahr, T Molina, B Sam Martin, J Pereira, A de Román, M H de Gómez, J J Villegas
• Journal: International journal of dermatology (Int J Dermatol) Vol. 27 Issue 9 Pg. 633-7 (Nov 1988) ISSN: 0011-9059 [Print] England
• PMID: 3229889 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Chemotaxis, Leukocyte
• Coccidioidomycosis (immunology)
• Female
• Granulomatous Disease, Chronic (immunology)
• Humans
• Liver Diseases, Alcoholic (immunology)
• Male
• Middle Aged
• Neutrophils (immunology)
• Psoriasis (immunology)