Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety during in vivo gene delivery.

Abstract

We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.

• Authors: Shengran Li , Lin Lin , Wenliang Wang , Xinxin Yan , Binggang Chen , Sangni Jiang , Sanrong Liu , Xiaojing Ma , Huayu Tian , Xifei Yu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 56 Issue 41 Pg. 5552-5555 (May 21 2020) ISSN: 1364-548X [Electronic] England
• PMID: 32297607 (Publication Type: Journal Article)

Chemical References

• Aza Compounds
• Crown Ethers
• Polyethyleneimine

Topics

• A549 Cells
• Animals
• Aza Compounds (administration & dosage, chemistry)
• Crown Ethers (administration & dosage, chemistry)
• Gene Transfer Techniques
• Humans
• Injections, Intravenous
• Mice
• Molecular Structure
• NIH 3T3 Cells
• Nanoparticles (administration & dosage, chemistry)
• Neoplasms, Experimental
• Optical Imaging
• Particle Size
• Polyethyleneimine (administration & dosage, chemistry)
• Surface Properties