Abstract |
Mice and rats of various ages (3, 10-12, and 18-19 months) were inoculated with the transplantation tumours murine melanoma B16 (B16), mammary adenocarcinoma 755 (Ca-755), leukemia P388 (P388), and rat rhabdomyosarcoma RA-2 (RA-2). Subcutaneous (sc) growth of B16 was not markedly affected by the age of the syngeneic host whereas intravenously (iv) inoculated 12 months old C57BL/6 mice developed more pulmonary metastases than animals 3 months of age. Median survival time (MST) of 18 months old mice bearing Ca-755 was significantly shorter than that of younger individuals. In contrast, old rats that had been injected RA-2 iv survived longer than controls. Survival of DBA/2 mice inoculated intraperitoneally (ip) with P388 cells was not influenced by the age of the host. The antineoplastic activity of ambazone and, to a less extent, of 5-fluorouracil against P388 was drastically lower in 12 months old mice than in 3 months old tumour bearers. Likewise a graduate loss of antineoplastic activity of ambazone against Ca-755 was observed with increasing age of the mice, whereas the effect of ambazone and 5-fluorouracil against RA-2 did not depend on the age of the rats. It is suggested that tumour-host interactions as well as pharmacokinetics of a given drug may underlie age-related changes.
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Authors | J Baumgart, N V Zhukovskaya, V N Anisimov |
Journal | Experimental pathology
(Exp Pathol)
Vol. 33
Issue 4
Pg. 239-48
( 1988)
ISSN: 0232-1513 [Print] Germany |
PMID | 3229459
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- 1,4-benzoquinone guanylhydrazone thiosemicarbazone
- Mitoguazone
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Aging
(physiology)
- Animals
- Antineoplastic Agents
(therapeutic use)
- Cell Division
- Female
- Fluorouracil
(therapeutic use)
- Leukemia P388
(drug therapy, pathology)
- Leukemia, Experimental
(pathology)
- Male
- Mammary Neoplasms, Experimental
(drug therapy, pathology)
- Melanoma, Experimental
(drug therapy, pathology)
- Mice
- Mice, Inbred C57BL
- Mitoguazone
(analogs & derivatives, therapeutic use)
- Neoplasm Metastasis
- Rats
- Rhabdomyosarcoma
(drug therapy, pathology)
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