Abstract |
Autoantibodies to different thyroid cell components in serum of patients with thyroid disease have been estimated by several methods. The TSH receptor antibodies (TRAb) have been detected in 77% of untreated Graves-Basedow, in 70% of thionamide drugs treated Graves-Basedow patients up to four months of the treatment and in 48% of patients with Hashimoto's thyroiditis. Microsomal antibodies (MAb) and thyroid plasma membrane antibodies (ATMA) have been detected in 84% and 68% respectively, in thionamide drugs treated Graves-Basedow and in 91% and 72% in Hashimoto's thyroiditis. The thyroglobulin antibodies have been detected in 42% of untreated Graves-Basedow, in 47% of thionamide drugs treated Graves-Basedow and in 77% of Hashimoto's thyroiditis. In 19% to 21% of patients with toxic nodular goiter underlying autoimmunological process have been established by the detection of high levels of serum autoantibodies (ATMA and MAb). In the non-toxic nodular goiter, non-thyroid autoimmune diseases and healthy blood donors only thyroglobulin antibodies were detected in a significant number of patients. Other types of antibodies (ATMA or MAb) were detected only in sporadic cases of non-thyroid autoimmune diseases.
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Authors | A Gardas, A Blottner, H Domek |
Journal | Experimental and clinical endocrinology
(Exp Clin Endocrinol)
Vol. 92
Issue 1
Pg. 77-84
(Sep 1988)
ISSN: 0232-7384 [Print] Germany |
PMID | 3229451
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Autoantibodies
(analysis)
- Autoimmune Diseases
(diagnosis, immunology)
- Diagnosis, Differential
- Diagnostic Tests, Routine
(methods)
- Graves Disease
(diagnosis, immunology)
- Humans
- Thyroid Diseases
(diagnosis, immunology)
- Thyroiditis, Autoimmune
(diagnosis, immunology)
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