Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyrromycin.

Abstract

The oligosaccharide-anthracyclines, aclacinomycin A, marcellomycin and musettamycin, are potent inducers of erythroid differentiation in hemopoietic cells lines of rodent and human origin. The present studies revealed that pyrromycin, a closely related monosaccharide-anthracycline, induced erythroid differentiation in Friend leukemia cells and in the human leukemia cell line K 562. Pyrromycin, marcellomycin and musettamycin, which possess an identical aglycone structure containing a Cl-hydroxyl group, exhibited relatively low optimal inductive concentrations. In contrast, the optimal inductive concentration of aclacinomycin A, which lacks the Cl-hydroxyl group, was markedly higher, i.e., the differentiation inducing capacity was lower. It should be noted, however, that the yield of differentiated cells following treatment with the monosaccharide-anthracycline pyrromycin was distinctly lower than that after treatment with the oligo-saccharide-anthracyclines, aclacinomycin A, marcellomycin or musettamycin. Thus, our data indicate that the efficacy of anthracyclines to induce erythroid differentiation is related to a) the presence of a Cl-hydroxyl group in the aglycone and b) the presence of an oligosaccharide side chain.

• Authors: G Steinheider, A Schaefer, J Westendorf, H Marquardt
• Journal: Cell biology and toxicology (Cell Biol Toxicol) Vol. 4 Issue 1 Pg. 123-33 (Mar 1988) ISSN: 0742-2091 [Print] Netherlands
• PMID: 3228706 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthracyclines
• Antibiotics, Antineoplastic
• pyrromycin
• Aclarubicin
• Doxorubicin

Topics

• Aclarubicin (pharmacology)
• Animals
• Anthracyclines
• Antibiotics, Antineoplastic (pharmacology)
• Cell Line
• Doxorubicin (pharmacology)
• Erythropoiesis (drug effects)
• Friend murine leukemia virus
• Humans
• Leukemia, Erythroblastic, Acute (pathology)
• Mice