[Antioxidant activity of hepatotropic preparations in the treatment of chronic diseases of the liver].

Abstract

Hepatotropic drugs were shown to decrease blood lipid peroxidation activity (LPO) in patients with chronic diffuse liver diseases. A positive time course of LPO indices was noted in the treatment of chronic active hepatitis and liver cirrhosis of moderate activity. Comparison of antioxidant features of the drugs were suggestive of a noticeable effect of trophopar and essential in patients with chronic active hepatitis, trophopar in patients with liver lipodystrophy, and drugs of a silimarina series in patients with liver cirrhosis. Under clinical conditions the effect of the drugs on LPO processes was less noticeable than in experiments in vitro. It is assumed that the pharmacological effect of the hepatotropic drugs is associated with their antioxidant activity.

• Authors: A S Loginov, B N Matiushin, G V Sukhareva, V D Tkachev
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 60 Issue 8 Pg. 74-7 ( 1988) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Antioksidantnaia aktivnost' gepatotropnykh preparatov pri lechenii khronicheskikh bolezneĭ pecheni.
• PMID: 3227482 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Silymarin

Topics

• Adult
• Antioxidants (therapeutic use)
• Chronic Disease
• Humans
• Lipid Peroxidation (drug effects)
• Liver (drug effects, metabolism)
• Liver Diseases (drug therapy, metabolism)
• Middle Aged
• Silymarin (therapeutic use)